Our research

Homeostasis refers to a regulatory process that stabilizes dynamic systems to counteract perturbations. Our research focuses on the dissection of molecular mechanisms stabilizing synaptic transmission through transsynaptic homeostatic plasticity. We employ a combination of genetic screens in Drosophila melanogaster and quantitative analysis of synaptic function and structure in Drosophila and mouse brain slices to uncover new molecular mechanisms underlying homeostatic plasticity. Furthermore, we analyze neural excitability and ion channel biophysics in neuronal cultures derived from patients with neurodevelopmental symptoms.